The neat thing about this tool is that it requires one to think visually about what one wants to present and create a narrative and visuals accordingly. The tool design lends itself to non-linear exploration of ideas. Being able to embed video and images seamlessly is another asset.

A neat series of  Prezi-tations  are Derek Bruff @ Vanderbilt:

Visual Thinking in University Teaching

and a follow-up annotation to that: Takeaways from VT

As tools such as Prezi enter the mainstream,  hopefully  more presenters will be inspired to  innovate in organizing their presentation materials.